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TRANSFORMING GROWTH FACTOR BETA1
Descriptors Found:
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DeCS
Descriptor
English
:
Transforming Growth Factor beta1
Descriptor
Spanish
:
Factor de Crecimiento Transformador beta1
Descriptor
Portuguese
:
Fator de Crescimento Transformador beta1
Synonyms
English
:
TGF-beta1
Tree Number:
D12.644.276.374.687.100
D12.644.276.954.775.100
D12.776.467.374.687.100
D12.776.467.942.775.100
D23.529.374.687.100
D23.529.942.775.100
Definition
English
:
A subtype of
transforming growth factor beta
that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and
TGF-beta1
latency-associated peptide. The
association
of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes
TGF-beta1
are the cause of
CAMURATI-ENGELMANN SYNDROME.
Entry Combination - descr/qualif
English
:
Transforming Growth Factor beta1
/
deficiency
use
Camurati-Engelmann Syndrome
History Note
English
:
2007(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52285
Unique Identifier:
D053773
Occurrence in VHL
:
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CID-10
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